The type of literature sources and content are crucial for a bibliographic application, as submitted work must be published by a reliable source and freely available in public domain. The data from own preclinical and clinical research may not be considered in the bibliographical application. Assessment reports, like EPAR for EU marketing authorizations or summary reports from competent authorities cannot be considered for transparency reasons. To establish the effectiveness and safety of a medical product, applicants must include both positive and negative literature data in their evidence and explain any missing information in a contentious manner.